Absorption ratio method was developed and validated for the determination of Levosulpiride and Pantoprazole in capsules. The method involved Q-absorption analysis based on the measurement of absorbance at two wavelengths, i.e λmax of Pantoprazole (287.8 nm) and Iso-absorptive point of both drugs (262.6 nm). Beer’s law was obeyed in the concentration range for LEVO was found to be in the range of 25-125 μg/ml and for PANTO 6-30 μg/ml. The results of analysis have been validated statistically and by recovery studies. The method was found to be simple, precise, reproducible and economical. Hence it is more suitable for routine analysis of these drugs in combined dosage forms.
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